Product Name :
Belotecan hydrochloride
Description:
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
CAS:
213819-48-8
Molecular Weight:
469.96
Formula:
C25H28ClN3O4
Chemical Name:
(19S)-19-ethyl-19-hydroxy-10-2-[(propan-2-yl)amino]ethyl-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione hydrochloride
Smiles :
Cl.CC[C@]1(O)C2C=C3C4=NC5=CC=CC=C5C(CCNC(C)C)=C4CN3C(=O)C=2COC1=O
InChiKey:
SJKBXKKZBKCHET-UQIIZPHYSA-N
InChi :
InChI=1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.|Product information|CAS Number: 213819-48-8|Molecular Weight: 469.96|Formula: C25H28ClN3O4|Chemical Name: (19S)-19-ethyl-19-hydroxy-10-2-[(propan-2-yl)amino]ethyl-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione hydrochloride|Smiles: Cl.CC[C@]1(O)C2C=C3C4=NC5=CC=CC=C5C(CCNC(C)C)=C4CN3C(=O)C=2COC1=O|InChiKey: SJKBXKKZBKCHET-UQIIZPHYSA-N|InChi: InChI=1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0.Phospho-Smad3 (Ser423/425) Antibody manufacturer /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 50 mg/mL (106.7α-Hydroxycholesterol web 39 mM).PMID:33087535 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.|In Vivo:|Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.|Products are for research use only. Not for human use.|
