Product Name :
PAT-1251
Description:
PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases.
CAS:
2007885-39-2
Molecular Weight:
399.34
Formula:
C18H17F4N3O3
Chemical Name:
(3R,4R)-1-(3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxybenzoyl)-4-fluoropyrrolidin-3-ol
Smiles :
NCC1=CC(=NC(=C1)OC1=CC(=CC=C1)C(=O)N1C[C@@H](F)[C@H](O)C1)C(F)(F)F
InChiKey:
ODGXXYXJORZPHE-ZIAGYGMSSA-N
InChi :
InChI=1S/C18H17F4N3O3/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22/h1-6,13-14,26H,7-9,23H2/t13-,14-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases.|Product information|CAS Number: 2007885-39-2|Molecular Weight: 399.34|Formula: C18H17F4N3O3|Chemical Name: (3R,4R)-1-(3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxybenzoyl)-4-fluoropyrrolidin-3-ol|Smiles: NCC1=CC(=NC(=C1)OC1=CC(=CC=C1)C(=O)N1C[C@@H](F)[C@H](O)C1)C(F)(F)F|InChiKey: ODGXXYXJORZPHE-ZIAGYGMSSA-N|InChi: InChI=1S/C18H17F4N3O3/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22/h1-6,13-14,26H,7-9,23H2/t13-,14-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 130 mg/mL (325.Blarcamesine Purity & Documentation 54 mM).Dapsone supplier |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32869553 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PAT-1251 is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 shows highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with Products are for research use only. Not for human use.|
