Product Name :
SK1-I
Sequence:
Purity:
≥98% (HPLC)
Molecular Weight:
313.9
Solubility :
Soluble in water or DMSO (100 mM).
Appearance:
White solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C.
Description:
Sphingosine kinase 1 inhibitor exclusive to Enzo Life Sciences SK1-I is a sphingosine analog and a sphingosine competitive inhibitor specific for sphingosine kinase 1 (SK1), with ki~10µM and excellent water solubility. It is not to be confused with SKI-I, 5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide, CAS 306301-68-8, a noncompetitive inhibitor of both SK1 and SK2 with poor water solubility (K.J. French, et al., 2006; N.J. Pyne and S. Pyne, 2010). SK1-I does not inhibit SK2, PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. Not only does it decrease sphingosine-1-phosphate levels, it also causes an accumulation of its proapoptotic precursor ceremide. Inhibits tumor cell growth in vitro and in vivo.
CAS :
1072443-89-0
Solubility:
Soluble in water or DMSO (100 mM).1497439-74-3 In stock
Formula:
C17H27NO2 .461432-26-8 web HCl
Additional Information :
| Alternative Name (2R,3S,4E)-N-methyl-5-(4′-pentylphenyl)-2-aminopent-4-ene-1,3-diol .PMID:30000420 HCl | Appearance White solid. | CAS 1072443-89-0 | Couple Target Sphingosine kinase | Couple Type Inhibitor | Formula C17H27NO2 . HCl | Identity Determined by NMR. | MW 313.9 | Purity ≥98% (HPLC) | Solubility Soluble in water or DMSO (100 mM). | Unit of Measure (UM) mg
