Se Committee in the San Raffaele Scientific Institute (IACUC 324, 335, 446, 447).Author contributionsASP, SN, DB, RQA, JH, KM and OTL developed and performed in vitro and in vivo experiments. ASP, SN, DB and SPG developed and performed animal studies. SE taught, supervised and offered expertise using the murine model of HLI. RS, AI, MW, PS, LGG and LN offered intellectual input in to the cellular and animal studies. MDP made and supervised Tie2 knockdown and Tie2-BMDM delivery studies. ASP, AS, MDP and BM offered crucial input in to the general research path. ASP, AS, MDP and BM wrote the paper with input from all co-authors who study, edited and approved the final copy on the manuscript.AcknowledgementsWe thank Anna Ranghetti and Ferdinando Pucci for assistance with BM transplantation and Susanne Heck, PJ Chana and Helen Graves for help with cell sorting. This study was funded by grants from the British Heart Foundation (to ASP: FS/09/061 and to BM: FS/11/37/28819) plus the British Heart Foundation Centre of Excellence at King’s College London (to ASP, AS and BM); the NIHR Biomedical Analysis Centre at Guy’s St Thomas’ NHS Foundation Trust and King’s College London (to ASP, AS and BM); the Royal College of Surgeons of England (to ASP); the Circulation Foundation (to BM) as well as the European Investigation Council (TIE2 MONOCYTES to MDP). Daniela Biziato carried out this study as partial fulfilment of her PhD in Molecular Medicine, Plan in Standard and Applied Immunology, San Raffaele University, Milan, Italy. Supporting Data is available at EMBO Molecular Medicine on line. The authors declare that they’ve no conflict of interest.
J Physiol 591.17 (2013) pp 4189Ionic mechanisms limiting cardiac repolarization reserve in humans in comparison to dogsNorbert Jost1,two , Lszlo Virg2 , Philippe Comtois10,11 , Balzs Ordg2,9 , Viktoria Szuts2 , Gyrgy Seprnyi3 , a a a o o e four 1 2 1 1 7 a a e a a a Miklos Bitay , Zsofia Kohajda , Istvn Koncz , Norbert Nagy , Tams Szl , Jnos Magyar , Mria Kovcs2 , e a a Lszlo G.Caprylic/Capric Triglyceride Biochemical Assay Reagents Pusks6 , Csaba Lengyel2,5 , Erich Wettwer8 , Ursula Ravens8 , Pter P.Inosine Autophagy Nnsi7 , Julius Gy.PMID:24428212 Papp1,2 , a a Andrs Varro1,2 and Stanley Nattel9,11 aThe Journal of PhysiologyDivision of Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged, Hungary Departments of two Pharmacology and Pharmacotherapy, 3 Medical Biology, and 4 Cardiac Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary five Very first Division of Internal Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary 6 Laboratory for Functional Genomics, Biological Study Center, Hungarian Academy of Sciences, Szeged, Hungary 7 Department of Physiology, Faculty of Medicine, University of Debrecen, Hungary 8 Division of Pharmacology and Toxicology, Dresden University of Technology, Germany Division of 9 Medicine and 10 Physiology, Universitde Montr l, Quebec, Canada e e 11 Analysis Center, Montreal Heart Institute, Montreal, Quebec, CanadaKey pointsCardiac repolarization, by means of which heart-cells return to their resting state immediately after getting fired, Animal models, especially the dog, are generally utilised to study repolarization properties andis a delicate approach, susceptible to disruption by typical drugs and clinical circumstances.responses to drugs, together with the assumption that such findings are relevant to humans. On the other hand, little is recognized regarding the applicability of findings in animals to man. Right here, we studied the contribution of several ion-currents to cardiac rep.
