Threat of UC. Folate, a water-soluble B vitamin in green leafy vegetables, citrus fruits, and legumes, could be the initial methyl donor in methionine biosynthesis [10]. Folate insufficiency disrupts the transfer from the one-carbon units involved in all biochemical reactions including plasma homocysteine determinants and SAM synthesis [11,20]. A earlier study investigated the 10-y trends in plasma folate levels in Taiwanese individuals through three national NAHSIT surveys performed in 199321996, 199922000, and 200522008 and reported comparable plasma folate levels of roughly 8 ng/mL in men and 11 ng/mL in females; on the other hand, the prevalence of folate deficiency (,three ng/mL) elevated through these 10-y periods, especially for guys [12]. In our study, the Nav1.4 Inhibitor MedChemExpress median value of plasma folate levels was equivalent to that reported by Chen et al. but was higher than that reported in other studies [12,21,22].Association of DNMT Polymorphism and Folate with the Danger of UCTable 2. Associations involving the levels of plasma folate and UC danger by utilizing multivariate logistic regression models.ORa (95 CI) 1.01 (0.99.03) ref. two.57 (1.73.84) ref. 0.42 (0.27.65) 0.44 (0.28.68) ref. 0.41 (0.26.68) 0.42 (0.26.68) 0.46 (0.28.75) ORb (95 CI) 1.02 (0.99.04) ref. two.06 (1.34.15) ref. 0.48 (0.30.76) 0.61 (0.38.97) ref.# 0.46 (0.27.77) 0.49 (0.29.83) 0.66 (0.39.11)Plasma folate (ng/mL) Median 6 S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 six.75.83 9.834.9 14.9 Incidence situations Median six S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 six.75.83 9.834.9 14.9 Prevalence situations Median six S.D. .six #6 ,7.88 7.883.17 13.17 ,6.75 6.75.83 9.834.9 14.aUC patients N = 192 7.7361.23 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 104 7.2861.33c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 88 eight.4562.17c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31)Controls N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15)0.99 (0.97.02) ref. three.09 (1.90.01) ref. 0.34 (0.19.61) 0.37 (0.22.65) ref. 0.38 (0.21.71) 0.33 (0.18.62) 0.37 (0.20.68)1.01 (0.99.04) ref. two.43 (1.45.06) ref. 0.40 (0.22.73) 0.53 (0.30.95) ref. 0.44 (0.23.84) 0.39 (0.20.76) 0.53 (0.28.03)1.03 (0.99.05) ref. 2.11 (1.24.60) ref. 0.52 (0.29.92) 0.50 (0.27.90) ref.# 0.44 (0.22.00) 0.53 (0.28.00) 0.56 (0.29.08)1.03 (0.99.05) ref. 1.76 (1.01.08) ref. 0.56 (0.31.01) 0.67 (0.36.25) ref. 0.45 (0.23.91) 0.60 (0.31.18) 0.76 (0.38.51)OR values had been adjusted for age and gender. OR values were adjusted for age, gender, educational level, and cumulative cigarette smoking. p = 0.1772 by Student t-test. p,0.05 by trend test; #0.1,p,0.05 by trend test. doi:10.1371/journal.pone.0104968.tb cMoreover, in our study, the prevalence of folate insufficiency was higher than that in other research, ranging from 5 to 15 [22]. The differences within the prevalence of folate insufficiency may possibly be attributed towards the ethnic PARP Inhibitor web variance of dietary habits or individual susceptibility to polymorphisms in metabolizing folate-related genes which include DNMT3A and 3B. Prior studies have indicated a damaging association amongst plasma.
