Chan K. et al., 2019 [210]CXCR3 Agonist site Randomized controlled Open-label, potential study54 patients with kind two diabetes0, six, 12 mg/day8 weeksTakami M. et al., 2019 [211]Open-label, prospective study20 healthier young male subjectsc.a, 4.five mg/day from salmon4 weeksMashhadi N.S. et al., 2018 [163]Randomized, double-blind, placebo-controlled, prospective study Randomized, double-blind, placebo-controlled, potential study44 participants with sort 2 diabetes0, 8 mg/day8 weeksCanas J. A. et al., 2017 [211]20 young children with easy obesity (BMI 90 )500 /day (MCS)6 monthsTakemoto M. et al., 2015 [212]Case report1 Werner syndrome patient12 mg/day six monthsNutrients 2022, 14,25 ofTable 3. Cont. Author/Year/Reference Ni Y. et al., 2015[108] Study Style Randomized, single-blind, placebo-controlled, prospective study Randomized, double-blind, placebo-controlled, prospective study Randomized, ouble-blind, placebo-controlled, potential study Subjects Dose Duration Outcome Enhanced steatosis (p 0.05), marginally improved lobular inflammation (p = 0.15) and NAFLD activity score (p = 0.08)12 NASH patients12 mg/day24 weeksChoi H.D. et al., 2011 [40]27 overweight subjects (BMI 25.0 kg/m2 ) 61 non-obese subjects with fasting serum triglyceride of 12000 mg/dL and with no diabetes and hypertension0, 20 mg/day12 weeksDecreased LDL chol and ApoB. (See Table 1. For other outcomes.) Many comparison: triglycerides were substantially decreased by 12 and 18 mg/day and HDL-cholesterol was considerably improved by 6 and 12 mg. Serum adiponectin was elevated by AX (12 and 18 mg/day), and changes in adiponectin were positively correlated with alterations in HDL-chol. When subjects who met the diagnostic criteria for metabolic syndrome in Japan (SBP 130 mmHg, DBP 85 mmHg, TG 150 mg/dL, FG 100 mg/dL) at the start off in the study had been chosen from four mg group, important decreased in SBP(p 0.01). On the other hand, there was no significant reduce in DBP. Decreased TG immediately after treatment (218 mg/dL) than the baseline worth (292 mg/dL), marginally decreased fasting glucose immediately after the intervention (p 0.1). Substantial decreases plasma HbAlc (p = 0.0433) and TNF- HIV-1 Activator Species levels (p = 0.0022) and boost adiponectin concentration (p = 0.0053). N.S: physique weight, BMI and waist circumference. Synergistic effects of AX intake (12 mg/day, 6 weeks) and aerobic exercising (walking) had been studied. AX contributed to reduction of body fat and suppressed the improve in blood lactate level following physical exercise. Increase HDL-chol levels in two mg and 8 mg group improved significantly just after 8 weeks from 50.6 5.8 to 60.four 7.1 mg/dL, 44.4 ten.7 to 49.four 2.7 mg/dL respectively (p 0.05). In the two mg group, triglyceride decreased considerably from 171.6 67.four mg/dL to 145.eight 5.1 mg/dL (p 0.05). (See Table 1. For other outcomes.)Yoshida H. et al., 2010 [161]0, 6, 12, 18 mg/day12 weeksSatoh A. et al., 2009 [213]Open-label, prospective study20 subjects at threat for creating metabolic syndrome (from 127 healthier subjects)4, (8, 20) mg/day4 weeks.Uchiyama A. et al., 2008 [162]Open-label, potential study Randomized, double-blind, placebo-controlled, prospective study17 subjects at risk for developing metabolic syndrome8 mg twice day3 monthsFukamauchi M. et al., 2007 [214]32 healthful subjects0, 6 mg/day6 weeksKim Y.K. et al., 2004 [50]Open-label, prospective study15 healthy postmenopausal female subjects0, two, eight mg/day8 weeks As well as AX, other nutrients including antioxidants have been made use of inside the study.Nutrients 2022, 14,26
