Ce tactics.Author Contributions: Conceptualisation, writing, critique, editing, D.R. and T.D.; Visualisation, D.R.; Supervision, funding acquisition, T.D. Both authors have study and agreed to the published version from the manuscript. Funding: This research was funded by the Bruno and Helene J ter Foundation. Information Availability Statement: The GWAS summary statistics for most on the research described in this text are accessible in the following online repositories, along with the respective cited research articles. Leo et al. (https://www.ebi.ac.uk/gwas/efotraits/EFO_0001061GWASCatalog, Accession ID GCST004833), Rashkin et al. (https://www.ebi.ac.uk/gwas/efotraits/EFO_000106 1GWASCatalog, Accession ID GCST90011816), UK Biobank (CC GWAS with female controls only, https://github.com/Nealelab/UK_Biobank_GWAS, file: 20001_1041.gwas.imputed_v3.female), and FinnGen freeze five (https://r5.finngen.fi/), Japan Biobank (https://pheweb.jp/). Acknowledgments: The authors would prefer to acknowledge the diligent scientists who’ve carried out large scale genomic research on cervical cancer and produced their datasets available for public use. We moreover thank Professor Peter Hillemanns for his continuous support. The pictures had been produced on Biorender.com. Conflicts of Interest: The authors declare no conflict of interest. The funders had no function inside the design in the study; within the collection, analyses, or interpretation of information; in the writing of your manuscript, or within the choice to publish the results.AbbreviationsHPV human papillomavirus; GWAS genome-wide association study; HLA human leukocyte antigen; HIV human immunodeficiency virus; PCR polymerase chain reaction; LSIL low grade squamous intraepithelial lesions; CIN cervical intraepithelial neoplasia stage; HSIL high grade squamous intraepithelial lesions; CIS carcinoma in situ; hrHPV higher threat HPV; RR relative danger; FRR familial RR; iCHAVs independent sets of correlated highly associated variants; QTL quantitative trait loci; eQTL expression QTL; metQTL methylation QTL; sQTL splicing QTL; pQTL protein QTL; PRS polygenic risk score; MR Mendelian randomisation; ChIP chromatin immunoprecipitation; 3C chromatin conformation capture; 4C chromatin conformation capture on chip; 5C chromatin conformation capture carbon copy; Hi-C high throughput chromatin conformation capture; ChIA-PET chromatin interaction analysis by paired-end tag sequencing; 4-Methylbenzylidene camphor Epigenetics CRISPR clustered consistently interspaced short palindromic repeats; MHC significant histocompatibility complex; LoF loss of function.
cancersReviewNew Advances in Liquid Biopsy Technologies for Anaplastic Lymphoma Kinase (ALK)–Positive CancerMatteo Villa 1 , Geeta G. Sharma 1,2 , Chiara Manfroni 1 , Diego Cortinovisand Luca Mologni 1, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy; [email protected] (M.V.); [email protected] (G.G.S.); [email protected] (C.M.) Department of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA Department of Oncology, San Gerardo Hospital, 20900 Monza, Italy; [email protected] Correspondence: [email protected] Summary: A new methodology of cancer testing, known as “liquid biopsy”, has been under investigation within the previous few years. It is according to blood tests that can be Biocytin Biological Activity analyzed by novel genetics and bioinformatics tools, in order to detect cancer, predict or adhere to the response to therapies and.
