Rs. ALKnegative group was 22 and the median survival time was 0.21 years.3.two. Variables Associated with the Prognosis for Key ALCL of from the CNS 3.two. elements Linked with the Prognosis for Primary ALCL the CNS As mentioned above, the average observation period for the 39 circumstances was 13 months. As pointed out above, the typical observation period for the 39 instances was 13 months. Univariate analyses through the logrank test for each and every demographic and medical factor (age, Univariate analyses via the logrank test for every single demographic and healthcare element (age,sex, ALK status, lesion multiplicity, meningeal lesions, MTX chemotherapy, and radiation therapy) showed statistically considerable differences inside the prognosis for age 40 years (p = 0.029), ALKpositive tumors (p = 0.005), and MTX remedy (p = 0.0009). Particularly, the 2year survival prices for ALKpositive and ALKnegative cases were 71 and 22 , respectively (Figure 3).Cancers 2021, 13,7 ofsex, ALK status, lesion multiplicity, meningeal lesions, MTX chemotherapy, and radiation therapy) showed statistically Cirazoline GPCR/G Protein important differences within the prognosis for age 40 years (p = 0.029), ALKpositive tumors (p = 0.005), and MTX therapy (p = 0.0009). Specifically, Cancers 2021, 13, x FOR PEER Evaluation 11 of 19 the 2year survival prices for ALKpositive and ALKnegative cases had been 71 and 22 , respectively (Figure 3).Figure three. Cont.Cancers 2021, 13, 4358 Cancers 2021, 13, x FOR PEER REVIEW8 of 15 12 ofprimary cell lymphoma of Figure three. KaplanMeyer curves for general survival for key anaplastic large cell lymphoma of the central nervous method for each in the following factors: age (a), ALK positivity (b), and MTX the central nervous method for every in the following variables: age (a), ALK positivity (b), and MTX remedy (c). ALK: anaplastic lymphoma kinase, MTX: methotrexate. treatment (c). ALK: anaplastic lymphoma kinase, MTX: methotrexate.Cox regression analysis was performed search for variables related to to prognosis. A Cox regression evaluation was performed toto look for variables relatedprognosis. As As a result, 40 40 years 0.039, HR 0.32 (0.11.95)), ALKpositive tumor (p = 0.010, HR a result, age age years (p =(p = 0.039, HR 0.32 (0.11.95)), ALKpositive tumor (p = 0.010, HR (0.08.71), and and MTXbased chemotherapy (p = HR 0.17 (0.05.56)) have been components 0.24 0.24 (0.08.71), MTXbased chemotherapy (p = 0.003, 0.003, HR 0.17 (0.05.56)) had been elements associated with a good prognosis. No statistically significant variations were obassociated with a very good prognosis. No statistically significant differences were observed in served in terms of or single or numerous lesions, lesions, or radiation radiation therapy terms of sex, singlesex,multiple lesions, meningealmeningeal lesions, ortherapy (Table three). (Table 3).Table three. Variables related to prognosis for primary anaplastic huge cell lymphoma from the central Table 3. method. nervous Variables related to prognosis for main anaplastic significant cell lymphoma of your central nervous method. Variables HR (95 CI) pValue Variables HR (95 CI) pValue Age 40 years 0.32 (0.11.95) 0.039 Age 40 years 0.32 (0.11.95) 0.039 Female sex 1.00 (0.22.49) 0.998 Female sex 1.00 (0.22.49) 0.998 ALK optimistic 0.24 (0.08.71) 0.010 ALK constructive 0.24 (0.08.71) 0.010 Several lesions two.23 (0.78.37) 0.135 Several lesions two.23 (0.78.37) 0.135 Meningeallesions 0.51 (0.16.67) 0.265 Meningeal lesions 0.51 (0.16.67) 0.265 Tumor resection 0.47 (0.14.60) 0.226 Tumor chemotherapy 0.47 (0.14.60) 0.
