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Z sk?and Tachezy Biology Direct (2015) 10:74 DOI 10.1186/s13062-015-0101-RESEARCHOpen AccessEvolutionary loss of peroxisomes ?not limited to parasitesVojtch Z sk?and Jan Tachezy*AbstractBackground: Peroxisomes are ubiquitous eukaryotic organelles that compartmentalize a variety of metabolic pathways that are primarily related to the oxidative metabolism of lipids and the detoxification of reactive oxygen species. The importance of peroxisomes is underscored by serious human diseases, which are caused by disorders in peroxisomal functions. Some eukaryotic lineages, however, lost peroxisomes. These organisms are mainly anaerobic protists and some parasitic lineages including Plasmodium and parasitic platyhelminths. Here we performed a systematic LIMKI 3 web in-silico analysis of peroxisomal markers among metazoans to assess presence of peroxisomes and peroxisomal enzymes. Results: Our analyses reveal an o.
